Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation

Brazilian Journal of Medical and Biological Research

P. Heldin¹ 

[1] ,Biomedical Center Ludwig Institute for Cancer Research Uppsala,Sweden

关键词: Hyaluronan;    Synthase;    Hyaluronidase;    Tumor invasion;    Extracellular matrix;    Pericellular matrix;   

DOI  :  10.1590/S0100-879X2003000800002

来源: SciELO

【 摘 要 】

Hyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions. Through its interactions with hyaladherins, hyaluronan affects several cellular functions such as cell migration and differentiation. The activities of hyaluronan-synthesizing and -degrading enzymes have been shown to be regulated in response to growth factors. During tumor progression hyaluronan stimulates tumor cell growth and invasiveness. Thus, elucidation of the molecular mechanisms which regulate the activities of hyaluronan-synthesizing and -degrading enzymes during tumor progression is highly desired.

【 授权许可】

CC BY   
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