Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos

Química Nova

Gustavo Luiz Paraginski²  Claiton Roberto Berticelli²  Priscilla Jussiani Zambiazi²  Vanessa Teixeira Kunz Paraginski²  Manfredo Hörner²  Aline Joana Rolina Wohlmuth Alves Dos Santos¹  Rosmari Hörner¹ 

[1] ,Universidade Federal de Santa Maria Departamento de Química Santa Maria RS ,Brasil

关键词: triazene;    biological activity;    multidrug-resistant isolates;   

DOI  :  10.5935/0100-4042.20140180

来源: SciELO

【 摘 要 】

Bacterial resistance to antibacterial agents is currently a major concern. We report the synthesis, in vitro antibacterial activity and toxicity toward Artemia salina of six diaryltriazene compounds bearing different substituent groups. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) values against standard strains (ATCC) and clinical isolates (including ESBL, MBL and AmpC strains) were good to very good, in the range 8 to 128 mg mL-1. Results suggest that hydroxyl, 4-carboxyl and 4-phenyldiazenil groups attached to the diaryltriazenes provide enhanced activity. Toxicity results showed very low LC50 values for three compounds (10-fold lower than DTIC).

【 授权许可】

CC BY-NC   
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