In vitro antibacterial activity and toxicity toward Artemia salina Leach of some triazene compounds

Quimica nova

Santos, Aline Joana Rolina Wohlmuth Alves dos¹  Paraginski, Vanessa Teixeira Kunz²  Paraginski, Gustavo Luiz²  Zambiazi, Priscilla Jussiani²  Berticelli, Claiton Roberto²  Hörner, Manfredo²  Hörner, Rosmari² 

[1] Universidade Federal de Pelotas, Pelotas, Brasil;Universidade Federal de Santa Maria, Santa Maria, Brasil

关键词: triazene;    biological activity;    multidrug-resistant isolates.;   

DOI  :  10.5935/0100-4042.20140180

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Bacterial resistance to antibacterial agents is currently a major concern. We report the synthesis, in vitro antibacterial activity and toxicity toward Artemia salina of six diaryltriazene compounds bearing different substituent groups. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) values against standard strains (ATCC) and clinical isolates (including ESBL, MBL and AmpC strains) were good to very good, in the range 8 to 128 mg mL-1. Results suggest that hydroxyl, 4-carboxyl and 4-phenyldiazenil groups attached to the diaryltriazenes provide enhanced activity. Toxicity results showed very low LC50 values for three compounds (10-fold lower than DTIC).

【 授权许可】

CC BY