Química Nova | |
Atividade antibacteriana in vitro e toxicidade frente à Artemia salina Leach. de alguns compostos triazenos | |
Gustavo Luiz Paraginski2  Claiton Roberto Berticelli2  Priscilla Jussiani Zambiazi2  Vanessa Teixeira Kunz Paraginski2  Manfredo Hörner2  Aline Joana Rolina Wohlmuth Alves Dos Santos1  Rosmari Hörner1  | |
[1] ,Universidade Federal de Santa Maria Departamento de Química Santa Maria RS ,Brasil | |
关键词: triazene; biological activity; multidrug-resistant isolates; | |
DOI : 10.5935/0100-4042.20140180 | |
来源: SciELO | |
【 摘 要 】
Bacterial resistance to antibacterial agents is currently a major concern. We report the synthesis, in vitro antibacterial activity and toxicity toward Artemia salina of six diaryltriazene compounds bearing different substituent groups. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) values against standard strains (ATCC) and clinical isolates (including ESBL, MBL and AmpC strains) were good to very good, in the range 8 to 128 mg mL-1. Results suggest that hydroxyl, 4-carboxyl and 4-phenyldiazenil groups attached to the diaryltriazenes provide enhanced activity. Toxicity results showed very low LC50 values for three compounds (10-fold lower than DTIC).
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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