Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies

Química Nova

Shweta Paroha²  Ravindra Dhar Dubey¹  Subrata Mallick² 

[1] ,Siksha O Anushandhan University School of Pharmaceutical Sciences Odisha,India

关键词: naproxen;    calcium carbonate;    in vitro dissolution;   

DOI  :  10.1590/S0100-40422014000100015

来源: SciELO

【 摘 要 】

Interaction and physicochemical characterization of dispersions of naproxen in calcium carbonate after freeze-drying the wet-state equilibrated mixture have been investigated by analytical methods. The FT-IR study revealed the acid-base reaction between naproxen and calcium carbonate. The DSC study indicated physical interaction and significantly diminished crystallinity of naproxen in the formulation containing higher quantities of calcium carbonate. Furthermore, the SEM study showed the reduced particle size and loss of crystalline morphology in the same sample. Drug release increased with the increase of calcium carbonate in the formulations. Formulation of naproxen with calcium carbonate in 1:2 ratio allowed its dissolution to the greatest extent (94.96%) while other compositions, 1:0.5 and 1:1, showed 80.86% and 78.30% release, respectively.

【 授权许可】

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