Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies

Química Nova

Mallick, Subrata¹  Paroha, Shweta¹  Indian Institute of Integrative Medicine, Jammu, India¹  Dubey, Ravindra Dhar¹  Siksha O Anushandhan University, Odisha, India¹ 

关键词: naproxen;    calcium carbonate;    in vitro dissolution.;   

DOI  :  10.1590/S0100-40422014000100015

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Interaction and physicochemical characterization of dispersions of naproxen in calcium carbonate after freeze-drying the wet-state equilibrated mixture have been investigated by analytical methods. The FT-IR study revealed the acid-base reaction between naproxen and calcium carbonate. The DSC study indicated physical interaction and significantly diminished crystallinity of naproxen in the formulation containing higher quantities of calcium carbonate. Furthermore, the SEM study showed the reduced particle size and loss of crystalline morphology in the same sample. Drug release increased with the increase of calcium carbonate in the formulations. Formulation of naproxen with calcium carbonate in 1:2 ratio allowed its dissolution to the greatest extent (94.96%) while other compositions, 1:0.5 and 1:1, showed 80.86% and 78.30% release, respectively.

【 授权许可】

Unknown