Interaction of naproxen with calcium carbonate: physicochemical characterization and in vitro drug release studies

Quimica nova

Dubey, Ravindra Dhar¹  Mallick, Subrata²  Paroha, Shweta² 

[1] Indian Institute of Integrative Medicine, Jammu, India;Siksha O Anushandhan University, Odisha, India

关键词: naproxen;    calcium carbonate;    in vitro dissolution.;   

DOI  :  10.1590/S0100-40422014000100015

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Interaction andphysicochemical characterization of dispersions of naproxen in calcium carbonateafter freeze-drying the wet-state equilibrated mixture have been investigatedby analytical methods. The FT-IR study revealed the acid-base reaction betweennaproxen and calcium carbonate. The DSC study indicated physical interactionand significantly diminished crystallinity of naproxen in the formulation containinghigher quantities of calcium carbonate. Furthermore, the SEM study showed thereduced particle size and loss of crystalline morphology in the same sample.Drug release increased with the increase of calcium carbonate in the formulations.Formulation of naproxen with calcium carbonate in 1:2 ratio allowed its dissolutionto the greatest extent (94.96%) while other compositions, 1:0.5 and 1:1, showed80.86% and 78.30% release, respectively.

【 授权许可】

CC BY