Determinação de nimesulida por análise por injeção em fluxo com detecção amperométrica de múltiplos pulsos

Química Nova

Amanda Barbosa Lima²  Sandro Cruz Chaves²  Leonardo Morais Da Silva²  Polyana Fernandes Pereira¹  Eduardo Mathias Richter¹  Wallans Torres Pio Dos Santos¹ 

[1] ,Universidade Federal dos Vales do Jequitinhonha e Mucuri Departamento de QuímicaMG ,Brasil

关键词: pulse amperometric detection;    nimesulide;    boron-doped diamond;   

DOI  :  10.1590/S0100-40422013000900004

来源: SciELO

【 摘 要 】

A simple and fast method for the determination of nimesulide (NI) using flow injection analysis with multiple-pulse amperometric (FIA-MPA) detection at a boron-doped diamond (BDD) electrode was developed. The method was based mainly on the application of a four-potential waveform, E1(det) = -0.8 V / 30 ms, E2(det) = 0.6 V / 30 ms, E3(det) = -0.4 V / 30 ms and E4(cleaning) = -0.45 V / 300 ms versus Ag/AgCl (3.0 mol L-1 KCl). NI was detected at three different electrode potentials, at which the nitro group undergoes different redox reactions. The proposed method was selective and sensitive (detection limit of 81.0 nmol L-1), and successfully applied for the determination of NI in pharmaceutical formulations, yielding similar results to those obtained by the reference method.

【 授权许可】

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