Determination of nimesulide by flow injection analysis with multiple-pulse amperometric detection

Quimica nova

Richter, Eduardo Mathias¹  Pereira, Polyana Fernandes¹  Silva, Leonardo Morais da²  Lima, Amanda Barbosa²  Santos, Wallans Torres Pio dos²  Chaves, Sandro Cruz² 

[1] Universidade Federal de Uberlândia, Brasil;Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brasil

关键词: pulse amperometric detection;    nimesulide;    boron-doped diamond.;   

DOI  :  10.1590/S0100-40422013000900004

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A simple and fast method for the determination of nimesulide (NI) using flow injection analysis with multiple-pulse amperometric (FIA-MPA) detection at a boron-doped diamond (BDD) electrode was developed. The method was based mainly on the application of a four-potential waveform, E1(det) = -0.8 V / 30 ms, E2(det) = 0.6 V / 30 ms, E3(det) = -0.4 V / 30 ms and E4(cleaning) = -0.45 V / 300 ms versus Ag/AgCl (3.0 mol L-1 KCl). NI was detected at three different electrode potentials, at which the nitro group undergoes different redox reactions. The proposed method was selective and sensitive (detection limit of 81.0 nmol L-1), and successfully applied for the determination of NI in pharmaceutical formulations, yielding similar results to those obtained by the reference method.

【 授权许可】

CC BY