Química Nova | |
Influência de processos antagônicos no desenvolvimento de sistema de análises em fluxo para a determinação espectrofotométrica de propiltiouracil em medicamentos | |
Rodolfo De Melo Magalhães Santana2  Mauro Korn2  Josué Carinhanha Caldas Santos1  | |
[1] ,Universidade do Estado da Bahia Departamento de Ciências Exatas e da Terra Salvador BA ,Brasil | |
关键词: tautomeric equilibrium; antagonist processes; propylthiouracil; | |
DOI : 10.1590/S0100-40422013000100017 | |
来源: SciELO | |
【 摘 要 】
A multi-commuted flow system was developed to determine propylthiouracil (PTU) based on the reaction of its thiol form with iminoquinone radical generated by the oxidation of N,N-dimethyl-p-phenylenediamine in an alkaline medium. PTU can be found in tautomeric forms and the tautomeric equilibrium was displaced to enhance the thiol form. However, the reaction product is unstable and its residence time in the flow path was carefully investigated. The proposed procedure showed good precision (< 1.5%) and a limit of detection (3s) of 0.11 mg L-1. High recoveries were obtained in the validation test. The procedure was employed for propylthiouracil determination in medications.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
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