Influência de processos antagônicos no desenvolvimento de sistema de análises em fluxo para a determinação espectrofotométrica de propiltiouracil em medicamentos

Química Nova

Rodolfo De Melo Magalhães Santana²  Mauro Korn²  Josué Carinhanha Caldas Santos¹ 

[1] ,Universidade do Estado da Bahia Departamento de Ciências Exatas e da Terra Salvador BA ,Brasil

关键词: tautomeric equilibrium;    antagonist processes;    propylthiouracil;   

DOI  :  10.1590/S0100-40422013000100017

来源: SciELO

【 摘 要 】

A multi-commuted flow system was developed to determine propylthiouracil (PTU) based on the reaction of its thiol form with iminoquinone radical generated by the oxidation of N,N-dimethyl-p-phenylenediamine in an alkaline medium. PTU can be found in tautomeric forms and the tautomeric equilibrium was displaced to enhance the thiol form. However, the reaction product is unstable and its residence time in the flow path was carefully investigated. The proposed procedure showed good precision (< 1.5%) and a limit of detection (3s) of 0.11 mg L-1. High recoveries were obtained in the validation test. The procedure was employed for propylthiouracil determination in medications.

【 授权许可】

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