Influence of antagonic processes on the development of flow analysis system for spectrophotometric determination of propylthiouracil in medications

Quimica nova

Santos, Josué Carinhanha Caldas¹  Korn, Mauro²  Santana, Rodolfo de Melo Magalhães² 

[1] Universidade Federal de Alagoas, Maceió, Brasil;Universidade do Estado da Bahia, Salvador, Brasil

关键词: tautomeric equilibrium;    antagonist processes;    propylthiouracil.;   

DOI  :  10.1590/S0100-40422013000100017

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A multi-commuted flow system was developed to determine propylthiouracil (PTU) based on the reaction of its thiol form with iminoquinone radical generated by the oxidation of N,N-dimethyl-p-phenylenediamine in an alkaline medium. PTU can be found in tautomeric forms and the tautomeric equilibrium was displaced to enhance the thiol form. However, the reaction product is unstable and its residence time in the flow path was carefully investigated. The proposed procedure showed good precision (< 1.5%) and a limit of detection (3s) of 0.11 mg L-1. High recoveries were obtained in the validation test. The procedure was employed for propylthiouracil determination in medications.

【 授权许可】

CC BY