Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Química Nova

Amanda De Melo Bezerra²  Antônio Cláudio Da Silva Lins²  Petrônio Filgueiras De Athayde-filho²  Marcelo Sobral Da Silva²  José Maria Barbosa-filho²  Celso Amorim Camara¹  Tania Maria Sarmento Silva¹  Vanessa Da Silva Luna¹  Creusioni Figueredo Dos Santos¹ 

[1] ,Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica João Pessoa PB ,Brasil

关键词: Licaria;    lignoids;    topoisomerase;   

DOI  :  10.1590/S0100-40422012001100024

来源: SciELO

【 摘 要 】

Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM, while none showed activity between 5 and 70 µM. These results indicate that no obvious correlation can be derived between the structure of these compounds and their inhibitory effect on the DNA relaxation activity of topoisomerase II. This is the first report on DNA topoisomerase II inhibitors from Licaria chrysophylla and Licaria aurea leading to the identification of lignoids as topoisomerase II-α inhibitors.

【 授权许可】

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