Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Química Nova

Silva, Marcelo Sobral da¹  Universidade Federal da Paraíba, João Pessoa, Brasil¹  Camara, Celso Amorim¹  Bezerra, Amanda de Melo¹  Universidade Federal Rural de Pernambuco, Recife, Brasil¹  Barbosa-Filho, José Maria¹  Lins, Antônio Cláudio da Silva¹  Athayde-Filho, Petrônio Filgueiras de¹  Luna, Vanessa da Silva¹  Santos, Creusioni Figueredo dos¹  Silva, Tania Maria Sarmento¹ 

关键词: Licaria;    lignoids;    topoisomerase.;   

DOI  :  10.1590/S0100-40422012001100024

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM, while none showed activity between 5 and 70 µM. These results indicate that no obvious correlation can be derived between the structure of these compounds and their inhibitory effect on the DNA relaxation activity of topoisomerase II. This is the first report on DNA topoisomerase II inhibitors from Licaria chrysophylla and Licaria aurea leading to the identification of lignoids as topoisomerase II-α inhibitors.

【 授权许可】

Unknown