Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Quimica nova

Camara, Celso Amorim¹  Silva, Tania Maria Sarmento¹  Silva, Marcelo Sobral da²  Bezerra, Amanda de Melo²  Barbosa-Filho, José Maria²  Lins, Antônio Cláudio da Silva²  Athayde-Filho, Petrônio Filgueiras de²  Luna, Vanessa da Silva²  Santos, Creusioni Figueredo dos² 

[1] Universidade Federal Rural de Pernambuco, Recife, Brasil;Universidade Federal da Paraíba, João Pessoa, Brasil

关键词: Licaria;    lignoids;    topoisomerase.;   

DOI  :  10.1590/S0100-40422012001100024

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA. All compounds tested showed strong inhibition at a concentration of 100 µM, while none showed activity between 5 and 70 µM. These results indicate that no obvious correlation can be derived between the structure of these compounds and their inhibitory effect on the DNA relaxation activity of topoisomerase II. This is the first report on DNA topoisomerase II inhibitors from Licaria chrysophylla and Licaria aurea leading to the identification of lignoids as topoisomerase II-α inhibitors.

【 授权许可】

CC BY