Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

Química Nova

Vanessa G. Rodrigues¹  Lucienir P. Duarte¹  Grácia D. F. Silva¹  Fernando C. Silva¹  Jefferson V. Góes¹  Jacqueline A. Takahashi¹  Lúcia P. S. Pimenta¹  Sidney A. Vieira Filho² 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Exatas Departamento de QuímicaBelo Horizonte MG ,Brasil

关键词: Maytenus imbricata;    Celastraceae;    pentacyclic triterpenes;   

DOI  :  10.1590/S0100-40422012000700017

来源: SciELO

【 摘 要 】

The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, ¹H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.

【 授权许可】

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