Química Nova | |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata | |
Duarte, Lucienir P.1  Universidade Federal de Ouro Preto, Ouro Preto, Brasil1  Góes, Jefferson V.1  Silva, Fernando C.1  Silva, Grácia D. F.1  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil1  Vieira Filho, Sidney A.1  Pimenta, Lúcia P. S.1  Rodrigues, Vanessa G.1  Takahashi, Jacqueline A.1  | |
关键词: Maytenus imbricata; Celastraceae; pentacyclic triterpenes.; | |
DOI : 10.1590/S0100-40422012000700017 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, 1H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.
【 授权许可】
Unknown
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RO201912050595797ZK.pdf | 1674KB | download |