Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

Química Nova

Duarte, Lucienir P.¹  Universidade Federal de Ouro Preto, Ouro Preto, Brasil¹  Góes, Jefferson V.¹  Silva, Fernando C.¹  Silva, Grácia D. F.¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil¹  Vieira Filho, Sidney A.¹  Pimenta, Lúcia P. S.¹  Rodrigues, Vanessa G.¹  Takahashi, Jacqueline A.¹ 

关键词: Maytenus imbricata;    Celastraceae;    pentacyclic triterpenes.;   

DOI  :  10.1590/S0100-40422012000700017

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, 1H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.

【 授权许可】

Unknown