Quimica nova | |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata | |
Duarte, Lucienir P.1  Silva, Fernando C.1  Góes, Jefferson V.1  Silva, Grácia D. F.1  Rodrigues, Vanessa G.1  Pimenta, Lúcia P. S.1  Takahashi, Jacqueline A.1  Vieira Filho, Sidney A.2  | |
[1] Universidade Federal de Minas Gerais, Belo Horizonte, Brasil;Universidade Federal de Ouro Preto, Ouro Preto, Brasil | |
关键词: Maytenus imbricata; Celastraceae; pentacyclic triterpenes.; | |
DOI : 10.1590/S0100-40422012000700017 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, 1H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.
【 授权许可】
CC BY
【 预 览 】
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