Química Nova | |
Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata | |
Vanessa G. Rodrigues1  Lucienir P. Duarte1  Grácia D. F. Silva1  Fernando C. Silva1  Jefferson V. Góes1  Jacqueline A. Takahashi1  Lúcia P. S. Pimenta1  Sidney A. Vieira Filho2  | |
[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Exatas Departamento de QuímicaBelo Horizonte MG ,Brasil | |
关键词: Maytenus imbricata; Celastraceae; pentacyclic triterpenes; | |
DOI : 10.1590/S0100-40422012000700017 | |
来源: SciELO | |
【 摘 要 】
The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, ¹H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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