Triterpenoids from Azorella trifurcata (Gaertn.) Pers and their effect against the enzyme acetylcholinesterase

Química Nova

Carlos Areche²  Patricia Cejas²  Pablo Thomas²  Aurelio San-martín²  Luis Astudillo¹  Margarita Gutiérrez¹  Luis A Loyola¹ 

[1] ,University of Chile Faculty of Sciences Department of ChemistrySantiago,Chile

关键词: Azorella;    Umbelliferae;    triterpenes;   

DOI  :  10.1590/S0100-40422009000800008

来源: SciELO

【 摘 要 】

The inhibition of the enzyme acetylcholinesterase is considered as a strategy for the treatment of Alzheimer's disease, senile dementia, ataxia, and myasthenia gravis. Three lanostane- and two cycloartane-type triterpenes, together with two mulinane-type diterpenes were isolated from petroleum ether extract of the whole shrub of Azorella trifurcata (Gaertn.) Pers. Their effect on the enzyme acetylcholinesterase was assessed as well. In addition, this is the first report of these triterpenes in the genus Azorella.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License