Triterpenoids from Azorella trifurcata (Gaertn.) Pers and their effect against the enzyme acetylcholinesterase

Quimica nova

Loyola, Luis A¹  Thomas, Pablo²  Cejas, Patricia²  San-Martín, Aurelio²  Areche, Carlos²  Astudillo, Luis³  Gutiérrez, Margarita³ 

[1] University of Antofagasta, Antofagasta, Chile;University of Chile, Santiago, Chile;University of Talca, Talca, Chile

关键词: Azorella;    Umbelliferae;    triterpenes.;   

DOI  :  10.1590/S0100-40422009000800008

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The inhibition of the enzyme acetylcholinesterase is considered as a strategy for the treatment of Alzheimer's disease, senile dementia, ataxia, and myasthenia gravis. Three lanostane- and two cycloartane-type triterpenes, together with two mulinane-type diterpenes were isolated from petroleum ether extract of the whole shrub of Azorella trifurcata (Gaertn.) Pers. Their effect on the enzyme acetylcholinesterase was assessed as well. In addition, this is the first report of these triterpenes in the genus Azorella.

【 授权许可】

CC BY