Triterpenoids from Azorella trifurcata (Gaertn.) Pers and their effect against the enzyme acetylcholinesterase

Química Nova

University of Chile, Santiago, Chile¹  Thomas, Pablo¹  Astudillo, Luis¹  Cejas, Patricia¹  Gutiérrez, Margarita¹  Loyola, Luis A¹  San-Martín, Aurelio¹  University of Talca, Talca, Chile¹  University of Antofagasta, Antofagasta, Chile¹  Areche, Carlos¹ 

关键词: Azorella;    Umbelliferae;    triterpenes.;   

DOI  :  10.1590/S0100-40422009000800008

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The inhibition of the enzyme acetylcholinesterase is considered as a strategy for the treatment of Alzheimer's disease, senile dementia, ataxia, and myasthenia gravis. Three lanostane- and two cycloartane-type triterpenes, together with two mulinane-type diterpenes were isolated from petroleum ether extract of the whole shrub of Azorella trifurcata (Gaertn.) Pers. Their effect on the enzyme acetylcholinesterase was assessed as well. In addition, this is the first report of these triterpenes in the genus Azorella.

【 授权许可】

Unknown