Quinina: 470 anos de história, controvérsias e desenvolvimento

Química Nova

Alfredo Ricardo Marques De Oliveira¹  Daiane Szczerbowski¹ 

[1] ,Universidade Federal do Paraná Departamento de Química Curitiba PR ,Brasil

关键词: quinine;    chemical industry;    Cinchona alkaloids;   

DOI  :  10.1590/S0100-40422009000700048

来源: SciELO

【 摘 要 】

After 470 years, a history of development, international seed smuggling and scientific development that caused deep changes in our society, has reached an end. In 1638, the countess of Chinchón contracted a disease while in the Amazon rain forest and was healed by a potion used by the native inhabitants. In 1856, William H. Perkin while attempting to obtain synthetic quinine, discovered the mauveína, a molecule that changed the world. The synthesis of quinine was also the subject of a bitter controversy among two excellent scientists of the 20th century. During centuries, quinine was the only hope against malaria disease and its exploration almost extinguished the Cinchona tree.

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