Determinação condutométrica de cloridrato de metformina em formulações farmacêuticas empregando nitrato de prata como titulante

Química Nova

Elen Romão Sartori¹  Willian Toito Suarez¹  Orlando Fatibello-filho¹ 

[1] ,Universidade Federal de São Carlos Departamento de Química São Carlos SP ,Brasil

关键词: conductometry titration;    metformin hydrochloride;    silver nitrate;   

DOI  :  10.1590/S0100-40422009000700043

来源: SciELO

【 摘 要 】

A simple, precise, rapid and low-cost conductometric titration method for the determination of metformin hydrochloride (MET) in pharmaceuticals using silver nitrate as titrant is proposed. The method was based on the chemical reaction between the chloride of metformin hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl(s). The method was applied for MET determination in three pharmaceuticals and the obtained results with proposed method were in close agreement with those results obtained using an official method of the British Pharmacopoeia, at a 95% confidence level.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License