Conductometric determination of metformin hydrochloride in pharmaceutical formulations using silver nitrate as titrant

Química Nova

Sartori, Elen Romão¹  Suarez, Willian Toito¹  Universidade Federal de São Carlos, São Carlos, Brasil¹  Fatibello-Filho, Orlando¹ 

关键词: conductometry titration;    metformin hydrochloride;    silver nitrate.;   

DOI  :  10.1590/S0100-40422009000700043

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A simple, precise, rapid and low-cost conductometric titration method for the determination of metformin hydrochloride (MET) in pharmaceuticals using silver nitrate as titrant is proposed. The method was based on the chemical reaction between the chloride of metformin hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl(s). The method was applied for MET determination in three pharmaceuticals and the obtained results with proposed method were in close agreement with those results obtained using an official method of the British Pharmacopoeia, at a 95% confidence level.

【 授权许可】

Unknown