Conductometric determination of metformin hydrochloride in pharmaceutical formulations using silver nitrate as titrant

Quimica nova

Sartori, Elen Romão¹  Suarez, Willian Toito¹  Fatibello-Filho, Orlando¹ 

[1] Universidade Federal de São Carlos, São Carlos, Brasil

关键词: conductometry titration;    metformin hydrochloride;    silver nitrate.;   

DOI  :  10.1590/S0100-40422009000700043

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A simple, precise,rapid and low-cost conductometric titration method for the determination ofmetformin hydrochloride (MET) in pharmaceuticals using silver nitrate as titrantis proposed. The method was based on the chemical reaction between the chlorideof metformin hydrochloride molecule and Ag(I) ions, yielding the precipitateAgCl(s). The method was applied for MET determination in three pharmaceuticalsand the obtained results with proposed method were in close agreement with thoseresults obtained using an official method of the British Pharmacopoeia, at a95% confidence level.

【 授权许可】

CC BY