Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Química Nova

Sílvia H. Cardoso²  João Vítor De Assis²  Mauro V. De Almeida²  Maria Cristina S. Lourenço¹  Felipe R. C. Vicente¹  Marcus V. N. De Souza¹ 

[1] ,Universidade Federal de Juiz de Fora Instituto de Ciências Exatas Departamento de QuímicaJuiz de Fora MG ,Brasil

关键词: isoniazid analogs;    carbohydrate;    antimycobacterial activity;   

DOI  :  10.1590/S0100-40422009000600038

来源: SciELO

【 摘 要 】

A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.

【 授权许可】

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