Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Química Nova

Almeida, Mauro V. de¹  Souza, Marcus V. N. de¹  Fundação Oswaldo Cruz, Rio de Janeiro, Brasil¹  Cardoso, Sílvia H.¹  Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil¹  Vicente, Felipe R. C.¹  Assis, João Vítor de¹  Lourenço, Maria Cristina S.¹ 

关键词: isoniazid analogs;    carbohydrate;    antimycobacterial activity.;   

DOI  :  10.1590/S0100-40422009000600038

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.

【 授权许可】

Unknown