Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Quimica nova

Souza, Marcus V. N. de¹  Vicente, Felipe R. C.¹  Lourenço, Maria Cristina S.¹  Almeida, Mauro V. de²  Cardoso, Sílvia H.²  Assis, João Vítor de² 

[1] Fundação Oswaldo Cruz, Rio de Janeiro, Brasil;Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil

关键词: isoniazid analogs;    carbohydrate;    antimycobacterial activity.;   

DOI  :  10.1590/S0100-40422009000600038

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A series of 13compounds analogous of isoniazid condensed with carbohydrate was synthesizedand evaluated for their in vitro antibacterial activity against Mycobacteriumtuberculosis H37Rv using Alamar Blue susceptibility test andthe activity expressed as the minimum inhibitory concentration (MIC90)in μg/mL.Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL)when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP)and could be a good starting point to develop new compounds against tuberculosis.

【 授权许可】

CC BY