Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid

Química Nova

Sérgio S. Funari²  Gert Rapp²  Frank Richter¹ 

[1] ,DESY EMBL Outstation Hamburg

关键词: PLA2;    lipid bilayer;    X-rays;   

DOI  :  10.1590/S0100-40422009000400015

来源: SciELO

【 摘 要 】

The product of catalytic activity of the enzyme phospholipase A2, which resembles the core unit of animal toxins, on phospholipids is a 1:1 mixture of lysolipid and fatty acid. This mixture was studied by time-resolved simultaneous small- and wide angle x-ray diffraction over the temperature range from 23 to 53.5ºC. An unusually large lamellar structure was observed, with d = 11 nm, contradicting the complex functional dimer model between lysolipid and fatty acid. It can be explained by formation of a "double-bilayer", a new phase consisting of two different bilayers, one formed by lysophospholipid and other by fatty acid, bound together by head group interactions. Its strucutre was confirmed by simulations of the X-ray scattering pattern.

【 授权许可】

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