Química Nova | |
Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity | |
Fabíola Branco Filippin2  Liliete Canes Souza2  Raul Cavalcante Maranhão1  | |
[1] ,Universidade Federal de Santa Catarina Centro de Ciências da Saúde Departamento de Análises ClínicasFlorianópolis SC ,Brasil | |
关键词: amphotericin B; lipid nanoemulsion; delivery system; | |
DOI : 10.1590/S0100-40422008000300024 | |
来源: SciELO | |
【 摘 要 】
Amphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells.
【 授权许可】
CC BY-NC
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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