期刊论文详细信息
Química Nova
Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
Fabíola Branco Filippin2  Liliete Canes Souza2  Raul Cavalcante Maranhão1 
[1] ,Universidade Federal de Santa Catarina Centro de Ciências da Saúde Departamento de Análises ClínicasFlorianópolis SC ,Brasil
关键词: amphotericin B;    lipid nanoemulsion;    delivery system;   
DOI  :  10.1590/S0100-40422008000300024
来源: SciELO
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【 摘 要 】

Amphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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