期刊论文详细信息
Química Nova | |
Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity | |
Hospital das Clínicas, São Paulo, Brasil1  Filippin, Fabíola Branco1  Universidade Federal de Santa Catarina, Florianópolis, Brasil1  Souza, Liliete Canes1  Maranhão, Raul Cavalcante1  | |
关键词: amphotericin B; lipid nanoemulsion; delivery system.; | |
DOI : 10.1590/S0100-40422008000300024 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
Amphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912050594117ZK.pdf | 108KB | download |