Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity

Quimica nova

Maranhão, Raul Cavalcante¹  Filippin, Fabíola Branco²  Souza, Liliete Canes² 

[1] Hospital das Clínicas, São Paulo, Brasil;Universidade Federal de Santa Catarina, Florianópolis, Brasil

关键词: amphotericin B;    lipid nanoemulsion;    delivery system.;   

DOI  :  10.1590/S0100-40422008000300024

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Amphotericin B (AB) is the standard drug forinvasive fungal infection therapy. It has a broad spectrum of activity and itis the best antifungal available against most yeasts and molds. Its therapeuticuse, however, is limited by significant side effects, leading to a low therapeuticindex when it is used as the traditional formulation (Fungizone®). Dueto self-association, AB can form pores in cholesterol-containing membranes.We propose a triglyceride-rich nanoemulsion as a delivery system for AB in lowlevels of aggregation to reduce the toxicity against host cells.

【 授权许可】

CC BY