Dissolution test for glibenclamide tablets

Química Nova

Elisabeth Aparecida Dos Santos Gianotto¹  Renata Pires Arantes¹  Maurilio José Lara-filho¹  Alexandre Cezar Saraiva Casimiro Filho¹  Marlene Maria Fregonezi-nery¹ 

[1] ,Universidade Estadual de Londrina Departamento de Ciências Farmacêuticas Londrina PR ,Brasil

关键词: glibenclamide;    dissolution test;    ultraviolet derivative spectrophotometry;   

DOI  :  10.1590/S0100-40422007000500031

来源: SciELO

【 摘 要 】

The aim of this work is to develop and validate a dissolution test for glibenclamide tablets. Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and using equipment with six vessels. The derivative UV spectrophotometric method for determination of glibenclamide released was developed, validated and compared with the HPLC method. The UVDS method presents linearity (r² = 0.9999) in the concentration range of 5-14 µg/mL. Precision and recoveries were 0.42% and 100.25%, respectively. The method was applied to three products commercially available on the Brazilian market.

【 授权许可】

CC BY-NC   
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