Dissolution test for glibenclamide tablets

Química Nova

Arantes, Renata Pires¹  Casimiro Filho, Alexandre Cezar Saraiva¹  Fregonezi-Nery, Marlene Maria¹  Lara-Filho, Maurilio José¹  Universidade Estadual de Londrina, Londrina, Brasil¹  Gianotto, Elisabeth Aparecida dos Santos¹ 

关键词: glibenclamide;    dissolution test;    ultraviolet derivative spectrophotometry.;   

DOI  :  10.1590/S0100-40422007000500031

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The aim of this work is to develop and validate a dissolution test for glibenclamide tablets. Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and using equipment with six vessels. The derivative UV spectrophotometric method for determination of glibenclamide released was developed, validated and compared with the HPLC method. The UVDS method presents linearity (r2 = 0.9999) in the concentration range of 5-14 µg/mL. Precision and recoveries were 0.42% and 100.25%, respectively. The method was applied to three products commercially available on the Brazilian market.

【 授权许可】

Unknown