Dissolution test for glibenclamide tablets

Quimica nova

Arantes, Renata Pires¹  Casimiro Filho, Alexandre Cezar Saraiva¹  Fregonezi-Nery, Marlene Maria¹  Lara-Filho, Maurilio José¹  Gianotto, Elisabeth Aparecida dos Santos¹ 

[1] Universidade Estadual de Londrina, Londrina, Brasil

关键词: glibenclamide;    dissolution test;    ultraviolet derivative spectrophotometry.;   

DOI  :  10.1590/S0100-40422007000500031

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The aim of this work is to develop and validatea dissolution test for glibenclamide tablets. Optimal conditions to carry outthe dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75rpm stirring speed, time test set to 60 min and using equipment with six vessels.The derivative UV spectrophotometric method for determination of glibenclamidereleased was developed, validated and compared with the HPLC method. The UVDSmethod presents linearity (r2 = 0.9999) in the concentration rangeof 5-14 µg/mL. Precision and recoveries were 0.42%and 100.25%, respectively. The method was applied to three products commerciallyavailable on the Brazilian market.

【 授权许可】

CC BY