Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer

Química Nova

Cláudio Viegas Junior²  Vanderlan Da Silva Bolzani²  Maysa Furlan²  Carlos Alberto Manssour Fraga¹  Eliezer J. Barreiro¹ 

[1] ,Universidade Estadual Paulista 'Júlio de Mesquita Filho' Instituto de Química Araraquara SP

关键词: Alzheimer's disease;    acetylcholinesterase;    natural products;   

DOI  :  10.1590/S0100-40422004000400021

来源: SciELO

【 摘 要 】

Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholine in the brain. There are only four commercial medicines approved for treatment of AD and natural products have played an important role in the research for new acetylcholinesterase inhibitors.

【 授权许可】

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