Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon

Memórias do Instituto Oswaldo Cruz

Omaira Vera Lizcano¹  Sarah Stela Resende¹  Yonne F Chehuan¹  Marcus Vg Lacerda¹  Cristiana Fa Brito¹  Mariano G Zalis¹ 

关键词: Plasmodium vivax;    chloroquine;    resistance;   

DOI  :  10.1590/0074-0276140241

来源: SciELO

【 摘 要 】

The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.

【 授权许可】

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