Relationship among epidemiological parameters of six childhood infections in a non-immunized Brazilian community

Memórias do Instituto Oswaldo Cruz

Marcos Amaku¹  Raymundo Soares Azevedo²  Ruy Morgado De Castro¹  Eduardo Massad²  Francisco Antonio Bezerra Coutinho¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Faculdade de Medicina Preventiva e Saúde AnimalSão Paulo SP ,Brasil

关键词: seroprevalence;    viral diseases;    epidemiology;    average age;    force of infection;    Monte Carlo method;   

DOI  :  10.1590/S0074-02762009000600013

来源: SciELO

【 摘 要 】

Epidemiological parameters, such as age-dependent force of infection and average age at infection () were estimated for rubella, varicella, rotavirus A, respiratory syncytial virus, hepatitis A and parvovirus B19 infections for a non-immunized Brazilian community, using the same sera samples. The for the aforementioned diseases were 8.45 years (yr) [95% CI: (7.23, 9.48) yr], 3.90 yr [95% CI: (3.51, 4.28) yr], 1.03 yr [95% CI: (0.96, 1.09) yr], 1.58 yr [95% CI: (1.39, 1.79) yr], 7.17 yr [95% CI: (6.48, 7.80) yr] and 7.43 yr [95% CI: (5.68, 9.59) yr], respectively. The differences between average ages could be explained by factors such as differences in the effectiveness of the protection conferred to newborns by maternally derived antibodies, competition between virus species and age-dependent host susceptibility. Our seroprevalence data may illustrate a case of the above-mentioned mechanisms working together within the same population.

【 授权许可】

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