Patterns of co-association of C-reactive protein and nitric oxide in malaria in endemic areas of Iran

Memórias do Instituto Oswaldo Cruz

Hossein Nahrevanian²  Jafar Gholizadeh¹  Mahin Farahmand²  Mehdi Assmar² 

[1] ,Pasteur Institute of Iran Department of Parasitology Tehran,Iran

关键词: C-reactive protein;    Iran;    nitric oxide;    malaria;    Plasmodium;   

DOI  :  10.1590/S0074-02762008000100006

来源: SciELO

【 摘 要 】

In addition to numerous immune factors, C-reactive protein (CRP) and nitric oxide (NO) are believed to be molecules of malaria immunopathology. The objective of this study was to detect CRP and NO inductions by agglutination latex test and Griess microassay respectively in both control and malaria groups from endemic areas of Iran, including Southeastern (SE) (Sistan & Balouchestan, Hormozgan, Kerman) and Northwestern (NW) provinces (Ardabil). The results indicated that CRP and NO are produced in all malaria endemic areas of Iran. In addition, more CRP and NO positive cases were observed amongst malaria patients in comparison with those in control group. A variable co-association of CRP/NO production were detected between control and malaria groups, which depended upon the malaria endemic areas and the type of plasmodia infection. The percentage of CRP/NO positive cases was observed to be lower in NW compare to SE region, which may be due to the different type of plasmodium in the NW (Plasmodium vivax) with SE area (P. vivax, Plasmodium falciparum, mixed infection). The fluctuations in CRP/NO induction may be consistent with genetic background of patients. Although, CRP/NO may play important role in malaria, their actual function and interaction in clinical forms of disease remains unclear.

【 授权许可】

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