Cells and mediators of inflammation (C-reactive protein, nitric oxide, platelets and neutrophils) in the acute and convalescent phases of uncomplicated Plasmodium vivax and Plasmodium falciparum infection

Memórias do Instituto Oswaldo Cruz

Josué Da Costa Lima-junior²  Rodrigo Nunes Rodrigues-da-silva²  Virgínia Araújo Pereira²  Fábio Luiz Storer¹  Daiana De Souza Perce-da-silva¹  Daniela Leite Fabrino¹  Fátima Santos¹  Dalma Maria Banic¹  Joseli De Oliveira-ferreira² 

[1] ,Instituto Oswaldo Cruz Laboratório de Imunoparasitologia Rio de Janeiro RJ ,Brasil

关键词: malaria;    C-reactive protein;    nitric oxide;    band neutrophils;   

DOI  :  10.1590/S0074-02762012000800012

来源: SciELO

【 摘 要 】

The haematological changes and release of soluble mediators, particularly C-reactive protein (CRP) and nitric oxide (NO), during uncomplicated malaria have not been well studied, especially in Brazilian areas in which the disease is endemic. Therefore, the present study examined these factors in acute (day 0) and convalescent phase (day 15) patients infected with Plasmodium falciparum and Plasmodium vivax malaria in the Brazilian Amazon. Haematologic parameters were measured using automated cell counting, CRP levels were measured with ELISA and NO plasma levels were measured by the Griess reaction. Our data indicate that individuals with uncomplicated P. vivax and P. falciparum infection presented similar inflammatory profiles with respect to white blood cells, with high band cell production and a considerable degree of thrombocytopaenia during the acute phase of infection. Higher CRP levels were detected in acute P. vivax infection than in acute P. falciparum infection, while higher NO was detected in patients with acute and convalescent P. falciparum infections. Although changes in these mediators cannot predict malaria infection, the haematological aspects associated with malaria infection, especially the roles of platelets and band cells, need to be investigated further.

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