Molecular evidence that human immunodeficiency virus type 1 dissemination in a small Brazilian city was already taking place in the early 1990s

Memórias do Instituto Oswaldo Cruz

Walter A Eyer-silva¹  Gonzalo Bello¹  Mariza G Morgado¹ 

[1] ,Fiocruz Instituto Oswaldo Cruz Laboratório de Aids & Imunologia MolecularRio de Janeiro RJ

关键词: Aids;    epidemiology;    human immunodeficiency virus type 1;    Brazil;   

DOI  :  10.1590/S0074-02762007000500018

来源: SciELO

【 摘 要 】

We recently performed a molecular epidemiology survey of human immunodeficiency virus type 1 (HIV-1) infection in Miracema, a small city in Southeast Brazil, and found multiple monophyletic clusters, consistent with independent introductions and spread of different viral lineages in the city. Here we apply Bayesian coalescent-based methods to the two largest subtype B clusters and estimate that the most recent common ancestors that gave rise to these two transmission chains were in circulation around 1991-1992. The finding that HIV-1 spread in this Brazilian small city was already taking place at a time Aids was considered a problem restricted to large urban centers may have important public health implications.

【 授权许可】

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