Memórias do Instituto Oswaldo Cruz | |
Molecular evidence that human immunodeficiency virus type 1 dissemination in a small Brazilian city was already taking place in the early 1990s | |
Walter A Eyer-silva1  Gonzalo Bello1  Mariza G Morgado1  | |
[1] ,Fiocruz Instituto Oswaldo Cruz Laboratório de Aids & Imunologia MolecularRio de Janeiro RJ | |
关键词: Aids; epidemiology; human immunodeficiency virus type 1; Brazil; | |
DOI : 10.1590/S0074-02762007000500018 | |
来源: SciELO | |
【 摘 要 】
We recently performed a molecular epidemiology survey of human immunodeficiency virus type 1 (HIV-1) infection in Miracema, a small city in Southeast Brazil, and found multiple monophyletic clusters, consistent with independent introductions and spread of different viral lineages in the city. Here we apply Bayesian coalescent-based methods to the two largest subtype B clusters and estimate that the most recent common ancestors that gave rise to these two transmission chains were in circulation around 1991-1992. The finding that HIV-1 spread in this Brazilian small city was already taking place at a time Aids was considered a problem restricted to large urban centers may have important public health implications.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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RO202005130047270ZK.pdf | 329KB | download |