The impact of depression on survival of Parkinson's disease patients: a five-year study

Jornal Brasileiro de Psiquiatria

Cláudia Débora Silberman¹  Cláudia Soares Rodrigues²  Eliasz Engelhardt¹  Jerson Laks¹ 

[1] ,Universidade Federal do Rio de JaneiroRio de Janeiro RJ ,Brazil

关键词: Parkinson's disease;    depression;    mortality;    Doença de Parkinson;    depressão;    mortalidade;   

DOI  :  10.1590/S0047-20852013000100002

来源: SciELO

【 摘 要 】

OBJECTIVE: The aim of this study is to evaluate the survival rate in a cohort of Parkinson's disease patients with and without depression. METHODS: A total of 53 Parkinson's disease subjects were followed up from 2003-2008 and 21 were diagnosed as depressed. Mean time of follow up was 3.8 (SD 95% = 1.5) years for all the sample and there was no significant difference in mean time of follow up between depressed and nondepressed Parkinson's disease patients. Survival curves rates were fitted using the Kaplan-Meier method. In order to compare survival probabilities according to the selected covariables the Log-Rank test was used. Multivariate analysis with Cox regression was performed aiming at estimating the effect of predictive covariables on the survival. RESULTS: The cumulative global survival of this sample was 83% with nine deaths at the end of the study - five in the depressed and four in the nondepressed group, and 55.6% died in the first year of observation, and none died at the fourth and fifth year of follow up. CONCLUSION: Our finding point toward incremental death risk in depressed Parkinson's disease patients.

【 授权许可】

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