HAART: a risk factor for development of porphyria cutanea tarda?

Revista da Sociedade Brasileira de Medicina Tropical

Fred Bernardes Filho²  Maria Victória Pinto Quaresma Santos²  Felipe Nazareth De Matos Pinto De Carvalho²  Carlos Gustavo Carneiro De Castro²  Elisabete Dobao²  Marcelo Rosandiski Lyra¹  Vinícius De Menezes¹  José Augusto Da Costa Nery² 

[1] ,Santa Casa da Misericórdia do Rio de Janeiro Instituto de Dermatologia Prof. Rubem David Azulay Rio de Janeiro RJ

关键词: Porphyria cutanea tarda;    HAART;    HIV;    Porfiria cutanea tarda;    HAART;    HIV;   

DOI  :  10.1590/S0037-86822012000600022

来源: SciELO

【 摘 要 】

Porphyria cutanea tarda (PCT) is caused by inherited or acquired partial deficiency of the uroporphyrinogen-decarboxylase (Uro-D) enzyme activity. It is the most common form of porphyria. The main triggering factors to the development of porphyria cutanea tarda are alcohol, hepatitis C virus and human immunodeficiency virus. There are several reports of PCT associated with drugs, among them, antiretroviral therapy. We describe three HIV-positive patients, which showed photosensitivity as well as the emergence of tense blisters on sun-exposed areas during the use of highly active antiretroviral therapy (HAART) and discuss the possibility of PCT after the use of these drugs by those patients.

【 授权许可】

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