期刊论文详细信息
Nutrients
The Effect of Spirulina platensis versus Soybean on Insulin Resistance in HIV-Infected Patients: A Randomized Pilot Study
Azabji-Kenfack Marcel1  Loni G. Ekali2  Sobngwi Eugene2  Onana E. Arnold2  Edie D. Sandrine1  Denis von der Weid4  Emmanuel Gbaguidi3  Jeanne Ngogang1 
[1] Department of Physiological Sciences and Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Melen Street, Cameroon;Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Melen Street, Cameroon;PPSAC/KfW/OCEAC, Yaounde, Cameroon;Antenna Technologies Foundation, Rue de Neuchâtel 29 1201 Geneva, Switzerland;
关键词: spirulina;    soybean;    insulin resistance;    HIV;    HAART;   
DOI  :  10.3390/nu3070712
来源: mdpi
PDF
【 摘 要 】

HIV-infected patients develop abnormalities of glucose metabolism due to the virus and antiretroviral drugs. Spirulina and soybean are nutritional supplements that are cheap, accessible in our community and affect glucose metabolism. We carried out a randomized study to assess the effect of Spirulina platensis versus soybean as a food supplement on HIV/HAART-associated insulin resistance (IR) in 33 insulin-resistant HIV-infected patients. The study lasted for two months at the National Obesity Centre of Cameroon. Insulin resistance was measured using the short insulin tolerance test. Physical activity and diet did not change over the study duration. On-treatment analysis was used to analyze data. The Mann-Whitney U test, the Students T test and the Chi square test were used as appropriate. Curve gradients were analyzed using ANCOVA. Seventeen subjects were randomized to spirulina and 16 to soybean. Each received 19 g of supplement daily. The follow up rate was 65% vs. 100% for spirulina and soybean groups, respectively, and both groups were comparable at baseline. After eight weeks, insulin sensitivity (IS) increased by 224.7% vs. 60% in the spirulina and soybean groups respectively (p < 0.001). One hundred per cent vs. 69% of subjects on spirulina versus soybean, respectively, improved their IS (p = 0.049) with a 1.45 (1.05–2.02) chance of improving insulin sensitivity on spirulina. This pilot study suggests that insulin sensitivity in HIV patients improves more when spirulina rather than soybean is used as a nutritional supplement. Trial registration: ClinicalTrials.gov identifier NCT01141777.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.

【 预 览 】
附件列表
Files Size Format View
RO202003190048870ZK.pdf 633KB PDF download
  文献评价指标  
  下载次数:8次 浏览次数:6次