HAART: a risk factor for development of porphyria cutanea tarda?

Revista da Sociedade Brasileira de Medicina Tropical

Carvalho, Felipe Nazareth de Matos Pinto de¹  Lyra, Marcelo Rosandiski¹  Santos, Maria Victória Pinto Quaresma¹  Dobao, Elisabete¹  Menezes, Vinícius de¹  Nery, José Augusto da Costa¹  Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro¹  Castro, Carlos Gustavo Carneiro de¹  Fundação Oswaldo Cruz, Rio de Janeiro¹  Bernardes Filho, Fred¹ 

关键词: Porphyria cutanea tarda;    HAART;    HIV;   

DOI  :  10.1590/S0037-86822012000600022

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Porphyria cutanea tarda (PCT) is caused by inherited or acquired partial deficiency of the uroporphyrinogen-decarboxylase (Uro-D) enzyme activity. It is the most common form of porphyria. The main triggering factors to the development of porphyria cutanea tarda are alcohol, hepatitis C virus and human immunodeficiency virus. There are several reports of PCT associated with drugs, among them, antiretroviral therapy. We describe three HIV-positive patients, which showed photosensitivity as well as the emergence of tense blisters on sun-exposed areas during the use of highly active antiretroviral therapy (HAART) and discuss the possibility of PCT after the use of these drugs by those patients.

【 授权许可】

Unknown