Revista da Sociedade Brasileira de Medicina Tropical | |
Serum proteins and fractions, HDL-cholesterol and total IgG and IgE levels in cases of acute and chronic paracoccidioidomycosis | |
Audrey De Souza Marquez2  Adriana Pardini Vicentini Moreira1  Paula Cesar Leonello1  Fernanda Akemi Nakanishi2  Eiko Nakagawa Itano1  | |
[1] ,State University of Londrina Department of Microbiology Microbiology Pos-Graduation ProgramLondrina PR ,Brazil | |
关键词: Immunoglobulin G; Immunoglobulin E; HDL-cholesterol; Paracoccidioidomycosis; Electrophoresis; Enzyme-linked immunoSorbent assay; Imunoglobulina G; Imunoglobulina E; HDL-colesterol; Paracoccidioidomicose; Eletroforese; Enzyme-linked immunoSorbent assay; | |
DOI : 10.1590/S0037-86822009000300002 | |
来源: SciELO | |
【 摘 要 】
This study evaluated serum protein fractions, HDL-cholesterol, total immunoglobulin G and total immunoglobulin E levels in patients with acute and chronic paracoccidioidomycosis, by means of electrophoresis, enzymatic reaction and immunoenzymatic assay. The results demonstrated elevated levels of total immunoglobulin G, total immunoglobulin E, alpha-2 and gamma-globulins, which were more evident in acute than in chronic PCM, but no increase in HDL-cholesterol levels. There was a correlation between the levels of total immunoglobulin E and gamma-globulins and the alpha-2 and beta-globulin fractions in the acute form and between beta and gamma-globulins in both the acute and the chronic form. In conclusion, changes in total immunoglobulin G and immunoglobulin E levels and in the electrophoretic profile may be important markers for the prognosis and therapeutic follow-up of PCM cases, especially because protein electrophoresis is a simple laboratory test that can be applied when specific PCM serological tests are not available. In addition, levels of the gamma-globulin fraction greater than 2.0g/dl may suggest that the patient is developing a more severe form of PCM.
【 授权许可】
CC BY
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