Serum proteins and fractions, HDL-cholesterol and total IgG and IgE levels in cases of acute and chronic paracoccidioidomycosis

Revista da Sociedade Brasileira de Medicina Tropical

Institute Adolfo Lutz, São Paulo, Brazil¹  Moreira, Adriana Pardini Vicentini¹  State University of Londrina, Londrina, Brazil¹  Itano, Eiko Nakagawa¹  Leonello, Paula Cesar¹  Nakanishi, Fernanda Akemi¹  Marquez, Audrey de Souza¹ 

关键词: Immunoglobulin G;    Immunoglobulin E;    HDL-cholesterol;    Paracoccidioidomycosis;    Electrophoresis;    Enzyme-linked immunoSorbent assay;   

DOI  :  10.1590/S0037-86822009000300002

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

This study evaluated serum protein fractions, HDL-cholesterol, total immunoglobulin G and total immunoglobulin E levels in patients with acute and chronic paracoccidioidomycosis, by means of electrophoresis, enzymatic reaction and immunoenzymatic assay. The results demonstrated elevated levels of total immunoglobulin G, total immunoglobulin E, alpha-2 and gamma-globulins, which were more evident in acute than in chronic PCM, but no increase in HDL-cholesterol levels. There was a correlation between the levels of total immunoglobulin E and gamma-globulins and the alpha-2 and beta-globulin fractions in the acute form and between beta and gamma-globulins in both the acute and the chronic form. In conclusion, changes in total immunoglobulin G and immunoglobulin E levels and in the electrophoretic profile may be important markers for the prognosis and therapeutic follow-up of PCM cases, especially because protein electrophoresis is a simple laboratory test that can be applied when specific PCM serological tests are not available. In addition, levels of the gamma-globulin fraction greater than 2.0g/dl may suggest that the patient is developing a more severe form of PCM.

【 授权许可】

Unknown