Duffy blood group genotypes among malaria patients in Rondônia, Western Brazilian Amazon

Revista da Sociedade Brasileira de Medicina Tropical

Carlos Eugênio Cavasini²  Fabrício José Tarelho Pereira²  Weber Luidi Ribeiro²  Gerhard Wunderlich¹  Marcelo Urbano Ferreira² 

[1] ,Faculdade de Medicina de São José do Rio Preto Laboratório de Parasitologia Molecular São José do Rio Preto SP

关键词: Plasmodium vivax;    Malaria;    Duffy antigen;    Genotypes;    Brazilian Amazon;    Plasmodium vivax;    Malária;    Antígeno Duffy;    Genótipos;    Amazônia Brasileira;   

DOI  :  10.1590/S0037-86822001000600016

来源: SciELO

【 摘 要 】

We have compared Duffy blood group genotype distribution, as determined by polymerase chain reaction with allele-specific primers, in 68 Plasmodium vivax-infected patients and 59 non-vivax malaria controls from Rondônia, Brazil. Homozygosity for the allele Fy, which abolishes Duffy antigen expression on erythrocytes, was observed in 12% non-vivax controls but in no P. vivax patient. However, no significant association was found between Fy heterozygosity and protection against P. vivax. The Fy x allele, which has recently been associated with very weak erythrocyte expression of Duffy antigen, was not found in local P. vivax patients.

【 授权许可】

CC BY   
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