Revista da Sociedade Brasileira de Medicina Tropical | |
Duffy blood group genotypes among malaria patients in Rondônia, Western Brazilian Amazon | |
Carlos Eugênio Cavasini2  Fabrício José Tarelho Pereira2  Weber Luidi Ribeiro2  Gerhard Wunderlich1  Marcelo Urbano Ferreira2  | |
[1] ,Faculdade de Medicina de São José do Rio Preto Laboratório de Parasitologia Molecular São José do Rio Preto SP | |
关键词: Plasmodium vivax; Malaria; Duffy antigen; Genotypes; Brazilian Amazon; Plasmodium vivax; Malária; Antígeno Duffy; Genótipos; Amazônia Brasileira; | |
DOI : 10.1590/S0037-86822001000600016 | |
来源: SciELO | |
【 摘 要 】
We have compared Duffy blood group genotype distribution, as determined by polymerase chain reaction with allele-specific primers, in 68 Plasmodium vivax-infected patients and 59 non-vivax malaria controls from Rondônia, Brazil. Homozygosity for the allele Fy, which abolishes Duffy antigen expression on erythrocytes, was observed in 12% non-vivax controls but in no P. vivax patient. However, no significant association was found between Fy heterozygosity and protection against P. vivax. The Fy x allele, which has recently been associated with very weak erythrocyte expression of Duffy antigen, was not found in local P. vivax patients.
【 授权许可】
CC BY
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